Application · VLP Characterization

Is this VLP not just the right size but also correctly folded?

Existing instruments can size a VLP. None of them can also confirm capsid folding with the same instrument, which is what RIPPLE's Raman channel now confirms.

Understand the Technology Talk to Our Team

BUILT FORFormulation / Process Development Scientists · QC / Release Scientists

What This Application Is Really Asking

Virus-like particles (VLPs) are non-infectious protein shells used as vaccine platforms. Most sizing instruments can confirm a VLP is the right size. None can confirm the capsid protein actually folded correctly, which determines whether the vaccine works. That's what RIPPLE's Raman channel is built to answer.

Key Parameters

STRUCTURAL / CHEMICAL ID

Raman channel

SIZE RANGE

3–400 nm

TURNAROUND

~60 seconds

What Makes RIPPLE Unique

1
Both folding confirmation and sizing The one question no sizing instrument can answer today.
2
One instrument for two workflows Chemical/structural confirmation fused with sizing, where today it needs a separate CD/DSC/cryo-EM step.
3
Results inside the same release window RIPPLE's ~60-second read fits inside the same testing window as your other release checks.