Application · Close-Sized Multi-Population Deconvolution
See target, degrader, and complex as three distinct populations.
RIPPLE’s groundbreaking sensitivity allows high resolution and differentiating between similar multi-populations, telling three closely-sized populations apart in a single read, reaching even into the demanding TPD ternary-complex window.
BUILT FORBiophysical / Structural Biology Scientists · Targeted Protein Degradation (TPD) program scientists
What This Application Is Really Asking
Given one possibly-impure sample, what's actually in it right now: how much free protein, bound complex, and self-aggregate? For TPD programs this tightens further: telling target, degrader, and the bound three-part complex apart, often within nanometers.
Key Parameters
POPULATION RESOLUTION
1.26× size gap
SINGLE-READ CAPABILITY
No titration needed
SMALL-PARTICLE FLOOR
Reaches TPD window
What Makes RIPPLE Unique
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1
Three populations, one measurement RIPPLE's resolution allows a three-way split beyond what is out there, reaching even the ~3–4.5 nm TPD ternary-complex window.
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2
Purpose-built for TPD programs RIPPLE's resolution is aimed specifically at telling target, degrader, and complex apart, not just spotting aggregates in general.
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3
Single read, and fast No titration series needed; RIPPLE's ~60-second read is faster than most existing instruments, as it requires no preparation or calibration.